Highly controlled chemistry of monolayer formation and end-capping. High column-to-column reproducibility. High selectivity and high efficiency for separations. Compatible with 100% aqueous mobile phase. Suitable for separations of peptides, proteins, and pharmaceuticals.
Utilizing highest purity and enhanced mechanical stability silica and pure bonding reagents, BR-C18 bonded phases have been innovatively and specially designed to ensure maximum surface coverage and full end-capping, which leads to carbon content as high as 19.0%. The bonding chemistry is completely controlled that results in very reliable column-to-column reproducibility. The maximum surface coverage allows BR-C18 to have exceptional stability, resulting in high pH stability in the range of 1.5 to 10.5.
Utilizing highest purity and enhanced mechanical stability silica and pure bonding reagents, BR-C18 bonded phases have been innovatively and specially designed to ensure maximum surface coverage and full end-capping, which leads to carbon content as high as 19.0%. The bonding chemistry is completely controlled that results in very reliable column-to-column reproducibility. The maximum surface coverage allows BR-C18 to have exceptional stability, resulting in high pH stability in the range of 1.5 to 10.5.
Highly controlled chemistry of monolayer formation and end-capping
Extremely high column-to-column reproducibility
High selectivity and efficiency for separations
pH range 1.5-10.5
Suitable for separations of acidic, neutral and basic compounds, peptides, and proteins
Column Stability at Alkali Conditions
BR-C18 uses full coverage bonded silica packing, which allows high stability at high pH. Figure below shows reproducible retention time for a test compound: toluene after 18,000 column volume runs in a mobile phase of 55% acetonitrile and 45% water at pH 10. Such high stability allows BR-C18 well suited for validation of various analytes at alkali conditions. The proprietary bonding chemistry for BR-C18 allows achieving high selectivity and high efficiency separation.
A BR-C18 column was operated at pH 10.
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