SpeedCore PFP columns will provide an alternative selectivity to that of traditional C18 reversed phased chemistries for the separation of basic, acidic and neutral species. PFP columns will retain by ion-exchange and shape selectivity mechanisms as well as both reversed and normal phase interactions. This makes them particularly useful for separation of closely related species such as isomers. The analyst is able to use buffer concentration as well as organic modifier to control retention factors of these dual mode selectivities.