Base material: cyclic oligosaccharides consisting of six (α-cyclodextrin), seven (β-cyclodextrin) or eight (γ-cyclodextrin) glucose units bonded through 1,4-linkages. Regioselective alkylation and / or acylation of the hydroxyl groups leads to lipophilic phases with varying enantioselectivity, which are well suited for GC enantiomer analysis. A large number of separations have been achieved, however, it is not possible to make a general prediction, which phase could solve a given separation task. Even for compounds with small structural differences or within homologous series the enantiodifferentiation can be quite different.

Column-Name	Phase	Tmax	Recommended Application
Lipodex A	hexakis-(2,3,6-tri-O-pentyl)-α-CD	200‒220°C	carbohydrates, polyols, diols, hydroxycarboxylic acid esters, (epoxy-) alcohols, glycerol derivatives, spiroacetals, ketones, alkyl halides
Lipodex B	hexakis-(2,6-di-O-pentyl-3-O-acetyl)-α-CD	200‒220°C	lactones, diols (cyclic carbonates), aminols, aldols (O-TFA), glycerol derivatives (cyclic carbonates)
Lipodex C	heptakis-(2,3,6-tri-O-pentyl)-β-CD	200‒220°C	Alcohols, cyanhydrins, oleins, hydroxycarboxylic acid esters, alkyl halides
Lipodex D	heptakis-(2,6-di-O-pentyl-3-O-acetyl)-β-CD	200‒220°C	aminols (TFA), β-amino acid esters, trans-cycloalkane-1,2-diols, trans-cycloalkane-1,2- diols, trans-cycloalkane-1,3-diols (TFA)
Lipodex E	octakis-(2,6-di-O-pentyl-3-O-butyryl)-γ-CD	200‒220°C	α-amino acids, α- and β-hydroxycarboxylic acid esters, alcohols (TFA), diols (TFA), ketones, pheromones (cyclic acetals), amines, alkyl halides, lactones
Lipodex G	octakis-(2,3-di-O-pentyl-6-O-methyl)-γ-CD	220‒240°C	menthol isomers, ketones, alcohols, carboxylic acid esters, terpenes