SpeedCore RP18-Amide features a single polar embedded stationary phase ligand, unlike some other commercial polar embedded phases produced by a multi-stage synthesis. As this is a single ligand bonding there are no uncontrolled secondary phase interactions. Therefore SpeedCore RP18-Amide provides highly reproducible performance from batch to batch. Selectivity of the RP18-Amide is different to that of a traditional C18 ligand and allows for separations of complex pairs not easily achieved on standard C18 stationary phases.