The C6 chain in Accucore Phenyl-Hexyl phase exhibits classical RP retention and selectivity, while the phenyl ring can add special selectivity by interacting with polar groups within the solutes. This results in a mixed-mode separation mechanism. The reduced hydrophobicity of this phase makes it ideal for the separation of very non-polar compounds. The Phenyl-Hexyl phase should be selected for complex samples where some peaks are well resolved on conventional alkyl phases, but are not well resolved on a conventional phenyl phase, or when other peaks are well resolved on a phenyl phase, but not well resolved on a conventional alkyl phase.